2015年8月28日金曜日

長女の方が次女より肥満?

長女の方が次女より肥満になりやすい


Research report
First-borns have greater BMI and are more likely to be overweight or obese: a study of sibling pairs among 26 812 Swedish women Press Release
José G B Derraik ,et. al.
J Epidemiol Community Health doi:10.1136/jech-2014-205368


妊娠の早いほう、最初に生まれた女性は、2番目に生まれた女性より BMI  0.57 kg/m2 (2.4%) 大きい (p <  0.0001)

加えて、長女は過体重 、肥満オッズ比高い  (OR 1.29; p < 0.0001 、1.40; p  <
 0.0001)


身長も、無視して良い大きさだが1.2mmほど高い


BMIは18年間のBMI増加の影響で、1年毎に 0.11 kg/m2の影響 (p <  0.0001)


ネガティブ思考は創造性の大元 悪いことだけではない


世の中、ネガティブ思考をけなす風潮が主流。


でも、最悪な状況に陥ったときの状況やその可能性を思考することってそんなに悪いことなのだろうか?

心理カウンセラーなどは、 単一思考におちいって、宗教のようにネガティブシンキングをけなすが・・・そんなにポジティブ思考って良いことだらけなのだろうか?
ポジティブ思考過ぎると、周りの皆さんにとても迷惑をかけてるはず・・・と、ネガティブに考えてみる。



Neurotics、神経症は、悩みを多く持ち、持ちたがる。だが、それは、創造性をもたらす性癖でもある

自分の考え、すなわち、自己形成された思考:Self-generated Thought(SGT)は、創造性を促進する一方、不幸を形成する。
mPFC(前頭前皮質内側部)の恐怖関連領域はブルーな傾向の自己形成思考を形成する。
高度神経症は、mPFC起因のSGTを含有する。



Thinking too much: self-generated thought as the engine of neuroticism Adam M. Perkinsemail, Danilo Arnone, Jonathan Smallwood, Dean Mobbs
DOI: http://dx.doi.org/10.1016/j.tics.2015.07.003


神経症も出るでは、不幸・創造性との関連性説明できず。


解説:何故か、ニュートンの神経症と関連づけ解説
Is neuroticism fueled by overthinking? Cell Press
http://www.eurekalert.org/pub_releases/2015-08/cp-inf082015.php


Isaac Newton’s neurotic creativity may have been down to negative thinking
Researchers link creativity with area of the brain used to perceive threat and danger
http://www.irishtimes.com/news/science/isaac-newton-s-neurotic-creativity-may-have-been-down-to-negative-thinking-1.2331329





Reconstructing and deconstructing the self: cognitive mechanisms in meditation practice
http://www.cell.com/trends/cognitive-sciences/abstract/S1364-6613(15)00152-7

瞑想にてメリハリを・・・


PCSK9阻害剤FDA承認2番目:Repatha(evolocumab)

 PCSK9阻害剤 Repatha(evolocumab)は、同クラス薬剤として2番目に、食事、スタチン治療最大量付加薬剤として、ヘテロ接合型家族性高コレステロール(HeFH)、ホモ接合型家族性高コレステロール血症(HoFH)、臨床的動脈硬化性心血管疾患への適応


 Alirocumab (サノフィ:trade name Praluent)に続く2番目の、proprotein convertase subtilisin–kexin type 9 (PCSK9)へのモノクローナル抗体




FDA News Release
FDA approves Repatha to treat certain patients with high cholesterol
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm460082.htm


ADA・AADE・AND合同ポジションステートメント:2型糖尿病自己管理教育・サポート

2型糖尿病の自己管理教育/サポート(DSME/S)は、一般にその価値が認められているが、現実には絶望的その機会は乏しい

ポジションステートメントで、そのエビデンスと戦略を提示


Diabetes Self-management Education and Support in Type 2 Diabetes: A Joint Position Statement of the American Diabetes Association, the American Association of Diabetes Educators, and the Academy of Nutrition and Dietetics
http://care.diabetesjournals.org/content/38/7/1372
http://care.diabetesjournals.org/content/early/2015/06/02/dc15-0730.full.pdf


















Overview of medical nutritiontherapy (MNT)

MNT is an evidence-based application of the nutrition care process provided by the registered dietitian nutritionist. It includes an individualize d nutrition assessment, nutrition diagnosis, intervention and monitoring, and evaluation and is the legal de fi nition of nutrition counseling by a registered dietitian nutritionist practicing in the U.S. (8)


1. Characteristics of MNT reducing HbA 1c by 0.5 – 2% for type 2 diabetes:

  • Series of three to four encounters with a registered dietitian nutritionist lasting from 45 to 90 min; the registered dietitian nutritionist should determine if additional encounters are needed
  • Series of encounters should begin at diagnosis of diabetes or at first referral to a registered dietitian nutritionist for MNT for diabetes and should be completed within 3 – 6 months
  • At least one follow-up encounter is recommended annually to reinforce lifestyle changes and to evaluate and monitor outcomes that indicate the need for changes in MNT or medication(s)


2. MNT provides nutrition assessment, nutrition diagnosis, and an intervention and management plan including the creation of individualized food plan and support for the following:

  • Individualized modification of food plan/physical activity/medication dosing for improved postprandial control, hypoglycemia prevention, and overall glycemic improvement
  • Individualized modification of carbohydrate, protein, fat, and sodium intake and guidance to achieve lipid and blood pressure goals
  • Individualized weight management planning and coaching
  • Education and support on additional topics to promote fl exibility in meal planning, food purchasing/preparation, recipe modification, and eating away from home
  • Individualized modification of food plan for managing related complications and comorbidities such as celiac disease, gastroparesis, eating disorders/disordered eating, kidney disease, etc.


3. CMS reimburses for diabetes MNT when provided by a quali fi ed practitioner (i.e., registered dietitian nutritionist). Many other payers also provide reimbursement. MNT services are included on the ADA and AADE DSME/S referral forms. A separate MNT referral form is available from the Academy of Nutrition and Dietetics at http://www.eatrightpro.org/ ; /media/eatrightpro%20 fi les/about%20us/what%20is%20an%20rdn% 20and%20dtr/mnt_referral_form_15_jul_14.ashx. Note: The Academy of Nutrition and Dietetics recognizes the use of registered dietitian (RD) and registered dietitian nutritionist (RDN). RD and RDN can only be used by those credentialed by the Commission on Dietetic Registration

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