重度低血糖2回以上経験の5年超診断後経過・1型糖尿病における、インスリンアナログと、ヒト・インスリンの重度低血糖リスク比較
Effect of insulin analogues on risk of severe hypoglycaemia in patients with type 1 diabetes prone to recurrent severe hypoglycaemia (HypoAna trial): a prospective, randomised, open-label, blinded-endpoint crossover trial
Dr Ulrik Pedersen-Bjergaard et. al.
The Lancet Diabetes & Endocrinology, Early Online Publication, 2 May 2014
・ analogue insulin (detemir and aspart) :レベミル
・ human insulin
(human neutral protamine Hagedorn and human regular) :