Clinical Features of Smokers with Radiological Emphysema but without Airway Limitation
Ana B. Alcaide et. al.
Chest. 2016. doi:10.1016/j.chest.2016.10.044
http://journal.publications.chestnet.org/article.aspx?articleid=2583285
203名の現行・既往喫煙、154名CT上気腫、49名該当せず
LDCT上の気腫患者では非気腫に比べた補正群間差比較
- 異常DLCO (<80 19="" p="0.02)</li" vs="">
- 6分間歩行距離SpO2%低下 >4% (8,5% vs 0%, p= 0,04)
- quality of life変化 (CAT score ≥ 10) (32% vs 14%, p=0.01)
CATアンケート項目の詳細解析で気腫患者では非気腫に比べ
- “chest tightness” score≥1 (p=0.05)
- “limitation when doing activities at home” items (p<0 .01="" li="" nbsp="">
- 1年前からの急性増悪有意差なし (0.19 vs 0.04, p=0.02)
2名の評価者：肺実質/window： 1,500 HU 、window center -650 HU
肺実質比率：: mild 0-25%, moderate 26-50%, severe 51-75% and very severe >75%
