遺伝子発現の季節性

Seasonal Effects on Gene Expression
Anita Goldinger ,  et. al.
PLOSone Published: May 29, 2015DOI: 10.1371/journal.pone.0126995


心理的問題から心血管疾患まで人間の健康状況の多くが季節変動を伴う。この現象の裏に、分子学的プロセスがあるはずで、６０６名の健康人を対象に７４＋９４のTranscriptの季節周期を検討


赤血球、血小板、好中球、単球、CD19の１２ヶ月周期性変動は有意

遺伝子発現や血液細胞に季節性環境的変動がなされ、健康成人でも重大な変化が存在する

Fig 1. Time series decomposition for TRIM23 (ILMN_1752741) using loess decomposition.
Original = The raw time-series data for the probe.
Seasonal = The regular cyclic component.
Trend = The linear drift over time.
Remainder = The irregular (error) component that is not explained by the seasonal and trend components.
doi:10.1371/journal.pone.0126995.g001

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Table 2. Biological enrichment for the 12 month seasonal cycle. doi:10.1371/journal.pone.0126995.t002