睡眠時間６時間未満だとワクチン効果低下

Sleep and antibody response to hepatitis B vaccination.
Prather AA et. al.
SLEEP 2012;35(8):1063-1069.

Experimental evidence links poor sleep with susceptibility to infectious illness; however, it remains to be determined if naturally occurring sleep is associated with immune responses known to play a role in protection against infection. The aim of this study was to determine whether sleep duration, sleep efficiency, and sleep quality, assessed in the natural environment, predict magnitude of antibody responses to a novel antigen among community volunteers in midlife.
Design:

対象：健康中年成人(n=125; 女性７０名；年齢４０-６０歳）、B型肝炎ワクチン標準３回シリーズ接種
actigraphyと電子睡眠日誌を用い睡眠時間評価、睡眠効率、睡眠の質評価


ウィルス特異的抗体を２回目、３回目ワクチン前に確認し一次・二次抗体反応として評価最終ワクチン接種後、６ヶ月後抗B型肝炎表面抗原IgG≧１０ mIU/mlをもって臨床的防御状態と判断



睡眠時間６時間より短いワクチン接種者は、７時間以上の睡眠ありのワクチン接種者に比べ、臨床的防御状態未到達リスク　１１．５倍超

最終ワクチン接種６ヶ月後約１５％ほどまだ抗体獲得できず。