ヒトの免疫・生理学周年的リズム、Circannual rhythmに関わる広汎な季節性遺伝子発現変化

周年的リズム、Circannual rhythmが遺伝子発現にも存在する

催炎症性Transcriptomic profileがヨーロッパの冬増加し、ｓSL-6受容体やCRP増加し、心血管系精神系自己免疫系疾患のバイオマーカー増加と共に冬にその疾患頻度ピークをもたらす


NATURE COMMUNICATIONS | ARTICLE OPEN
Widespread seasonal gene expression reveals annual differences in human immunity and physiology
Xaquin Castro Dopico, et. al.
Nature Communications 6, Article number: 7000 doi:10.1038/ncomms8000
Received 09 September 2014 Accepted 23 March 2015 Published 12 May 2015




Seasonal mRNA expression in the peripheral human immune system.