2013年11月27日水曜日

network meta-analysisによるCOPDにおけるLABA臨床的効果比較

MCID(Δ)を考えてないからよく考えてみたら、非劣性とはちょっと異なると思う。


同等性・非劣性試験

http://intmed.exblog.jp/3307656



network  meta-analysisによる、COPDにおけるLABA臨床的効果比較
Comparative efficacy of long-acting bronchodilators for COPD - a network meta-analysis
Respiratory Research 2013, 14:100 doi:10.1186/1465-9921-14-100 



Interpretation of the relative treatment effects resulting from the network meta-analysis for continuous and binary outcomes.

CFB=Change from baseline; D=difference in CFB; FEV1=Forced expiratory volume; OR=odds ratio; SGRQ=St. George’s Respiratory Questionnaire; TDI=Transitional Dyspnoea Index; d=0 indicates that the dotted line is equal to a difference in CFB between the treatments of zero for continuous endpoints (i.e. no difference between treatments); OR=1 indicates that the dotted line is equal to an odds ratio of one for binary endpoints (i.e. no difference between treatments). Cope et al. Respiratory Research 2013 14:100 doi:10.1186/1465-9921-14-100











Overview of the network meta-analysis results for trough FEV1, post-dose FEV1, SGRQ total score, and TDI total score at 6 months.

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